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Colitrol IV Injection
Calcitriol, the active metabolite of Vitamin D3, plays a critical role in:
- Promoting intestinal calcium absorption.
- Regulating bone mineralization.
- Maintaining calcium homeostasis, including stimulating osteoblastic activity in the skeleton.
Calcitriol is naturally synthesized in the kidneys from 25-hydroxycholecalciferol and is essential for bone health and calcium-phosphorus balance.
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Colitrol is indicated for the management of:
- Post-menopausal osteoporosis
- Renal osteodystrophy
- Postsurgical hypoparathyroidism
- Idiopathic hypoparathyroidism
- Pseudohypoparathyroidism
- Secondary hyperparathyroidism in moderate to severe chronic renal failure (pre-dialysis)
- Vitamin D-dependent rickets
✔️ Dosage & Administration
Dosing recommendations are based on serum calcium levels and the condition being treated.
Post-menopausal Osteoporosis:
- Oral dose: 0.25 mcg twice daily.
Renal Osteodystrophy (dialysis patients):
- Initial dose: 0.25 mcg daily.
- For normal or slightly reduced calcium levels: 0.25 mcg every other day may suffice.
Hypoparathyroidism and Rickets:
- Initial dose: 0.25 mcg/day (in the morning).
- If no response in 2–4 weeks, increase the dose at 2–4-week intervals.
Secondary Hyperparathyroidism (Pre-dialysis):
- Adults and children aged ≥3 years: 0.25 mcg/day, increased to 0.5 mcg/day if needed.
- Children aged <3 years: 10–15 ng/kg/day.
Intravenous administration:
- Initial dose: 1 mcg (0.02 mcg/kg) to 2 mcg three times weekly (every other day).
- Doses can range from 0.5 mcg to 4 mcg based on severity and response.
- Dose adjustments should occur at 2–4-week intervals.
- Children:
- Pre-dialysis secondary hyperparathyroidism: Initial dose is 10–15 ng/kg/day for children <3 years.
- Elderly:
- No specific dose adjustments are required.
✔️ Side Effects
Early side effects:
- Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, metallic taste.
Late side effects:
- Polyuria, polydipsia, anorexia, weight loss, conjunctivitis (calcific), pancreatitis, photophobia, pruritus, nocturia, rhinorrhea, cardiac arrhythmias, and rarely psychosis.
Injection-related side effects:
- Occasional mild pain at the injection site.
✔️ Interaction
Thiazide diuretics:
- Risk: Increases hypercalcemia risk.
- Recommendation: Monitor calcium levels closely.
Digitalis treatment:
- Risk: Hypercalcemia may precipitate cardiac arrhythmias.
- Recommendation: Use with caution.
Magnesium-containing drugs:
- Risk: May cause hypermagnesemia.
- Recommendation: Avoid concurrent use.
✔️ Contraindications
- Known hypersensitivity to any component of Colitrol.
- Diseases associated with hypercalcemia.
✔️ Pregnancy & Lactation
- Pregnancy: Use only if benefits outweigh potential risks.
- Lactation: Serum calcium levels of mother and infant should be monitored during breastfeeding.
✔️ Precautions & Warnings
- Avoid excessive dosage as it may cause hypercalcemia and, in some cases, hypercalciuria.
- Use cautiously in patients receiving digitalis to prevent cardiac arrhythmias.
- Discontinuation may cause a rebound effect; adjust the dose downward carefully.
- Vitamin D and its derivatives should not be administered during Colitrol therapy.
- Chronic hypercalcemia can lead to:
- Generalized vascular calcification.
- Nephrocalcinosis.
- Soft tissue calcification.
- Use a non-aluminum phosphate binder to control serum phosphorus levels in dialysis patients.
✔️ Storage Conditions
- Store in a dry place, away from light and heat.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
